No, not like that, but make the frame equally wide on all sides. Although it also depends on the furnishing. If there are almost furniture everywhere where the oddly thick frame is in the sketch, that would be a different matter again.
You only have the one offset because of the stairs?
In the end, you'll be standing there with the tiler, he'll lay the tiles test-wise, and then you'll know.
Diagonal is also pretty cool … ;-D