Much has already been said, I will not repeat it.
Just a small remark: as has been noted several times, you would probably be able to accommodate your space requirements a bit more cost-effectively on 2 floors.
If the wheelchair-bound son absolutely must/have to have the possibility to get to the second floor, then a so-called home lift could possibly really be an option. Space requirement is about 1.2x1m and it can initially just be set up as an option (i.e. planned breakthrough in the ceiling). This is not exorbitantly expensive and, unlike the classic stairlift, very well suited for wheelchair users.
What I also find a little lacking is the consideration whether a care service might possibly be needed at some point. Then one would also have to think about how to possibly accommodate it. Then I find the concept over two floors very sensible again. Downstairs a disabled-accessible bathroom with a disabled room plus a caregiver’s room (which can then be used as a bedroom or as a care service room), upstairs three/four rooms for any use (children, guests, bedroom, office) and a normal family bathroom.
As I said, I don’t know your situation exactly now, whether a care service room will ever be necessary or not. But keep in mind that your son will grow bigger and heavier, that other children will also want to be cared for, and at some point the time may come when you simply can no longer manage on your own. I have this situation in the wider circle of acquaintances (son a severely spastic but mentally completely fit), there one also always thought it would go without, but just wait till puberty comes, then the cards will be reshuffled.