Before we misunderstand each other now…
To your questions
Garage aligned flush with the house or set back?
is clarified with this specification:
Driveway or space in front of the garage at least 6 m.
rather modern construction style.
I don’t really find that the house is modern inside. An open space and, how do you say it so nicely here in the forum (well, not me), an aircraft carrier do not necessarily make a house modern inside.
43.5 sqm + 4 sqm pantry sufficient as a “multi-purpose room”?
One cannot say that as a principle, since the layout plays a role.
43 sqm can be enough, but then please not with an oversized island that needs 60 sqm of space, at least a kitchen that allows the flow of the daily activities. Because here it is docked exactly where one actually wants to enter the kitchen on a short path. The kitchen is a loop with a bottleneck that leads to a room that should be accessible quickly (meaning from the entrance, viewed from the hallway).
Regarding the dining area: 3 meters width, that is a given. Then also ensuring that you can reach the terrace door without slalom. The living room should get a TV spot that is important for you. I don’t see any of that – too tight and too long.
I would therefore shape the multi-purpose room more like an L: dining in the SW, kitchen in the S, relaxing in the NW. Above that, ideally the bedroom.
Same floor plan possibly mirrored?
No, the floor plan has too many flaws for that, even if your wishes are fulfilled, they are still there. And you are here so that these flaws can be pointed out to you.
But then office on the south side, sun all day, blinds always down. Same thing upstairs with the bedroom in summer at least.
Well, in winter you will be glad when enough daylight comes in there. Guests will certainly also prefer sunny. Just to note: your dad’s room is also on the south with few square meters!
I would always assign side rooms, if possible, to the darker location, living spaces to the brighter one. Shading is a topic anyway, and if you are aware of it, you can plan windows quite well so that you don’t have to cook.
Upstairs I would try to assign the “narrower half of the house” to the side rooms, because they can handle it. Bathroom, laundry, and dressing rooms suit that well. The bedroom then in the NW. Children’s rooms in the bright south then with the 3,x meters. That has to be looked at.
Of course, not everything can be implemented as in theory, but at least that is how I would initially arrange the rooms.