My brother-in-law (timber frame house with EPS insulation, foil, controlled residential ventilation without enthalpy exchanger) said the other day that he currently has 20-25% humidity and - no joke - he is getting cracked to slightly bloody hands.
20 - 25% is already extremely dry and certainly unhealthy. An enthalpy heat exchanger for about 800 EUR would mitigate the problem, but probably not solve it. In other words, you won’t reach the optimal 45-55% even with it.
With central controlled residential ventilation
without the exchanger, we currently have an average of about 35-40%. In some rooms even only 32%. Certainly not optimal either, but almost "normal" in winter, independently of controlled residential ventilation.
In our house, controlled residential ventilation is among the most appreciated features of the new build. We were really looking forward to it beforehand and love it in everyday life :) Therefore, for us it also applies "never again without."
By the way, ours usually runs at the medium level and is NOT audible except for a single valve (where I need to adjust the settings once). Especially in the bedrooms, controlled residential ventilation is a benefit and ensures constantly fresh/clean air without being noticeable! And I also claim that especially here the argument about "open doors" probably does not apply, since most people probably close their bedrooms at night!?