How can the bypass circuit be activated, or does it only exist in central systems?
Proper bypass circuits normally only exist in central units. In decentralized ones that recover heat through direction change, it is possible as M.O. wrote by disabling the direction change.
Only through insulation, a new roof or new windows and doors is airtightness achieved, which could subsequently lead to mold. This strongly limits natural infiltration.
Sort of, yes through a new roof, windows and doors, but insulation has nothing to do with it there. When the mentioned things are replaced, airtightness is naturally considered during implementation. New windows/doors are of course airtight, but independently of their insulation value.
Airtightness in doors/windows is achieved through seals, in the roof by vapor barrier foil, transitions by bonding etc., and in walls by the interior plaster. In the roof, insulation lies above the vapor barrier, and in the walls outside the interior plaster.
Simply replacing windows and doors, without insulating the roof and walls, already requires a change in previous ventilation behavior.