Hey,
first of all, I would be interested in the cardinal directions, the course of the street, and possibly any special features!
If all that fits:
I would make the access to the guest bathroom from the hallway! I would lead the staircase in two parts around the corner and swap it with the dining room. Upstairs, of course, a lot would change as well, but I think to the advantage, since the office no longer has to be so cramped and the children's room gets a more comfortable access.
If the staircase should stay there:
Try to get a straight line of access to the dressing room, office, and children's room! The mini entrance area in the dressing room is useless anyway, better make the hallway bigger there!
Contrary to the other opinion, I don't find two doors to the bathroom bad at all! But I would divide it differently, anyway, if the access is somewhere else!
Overall, try to avoid the many corners upstairs, these 1x1 m entrance areas! That is a waste of space...
Try to draw as few lines as possible!
Best regards,
Traumhaus2013