Exorbitant power consumption house construction single-family house experiences

There are 2 Daikin Altherma 3 H HT 14 KW each with 9KW backup heating (heating element). Air/water heat pump

Am I responsible for regulating these during the construction phase?

What does the contract say? Usually, yes.

How high is the consumption for such a screed program? If you divide your 46,000 kWh by one year, that would be a continuous consumption of 5.25 kW 24/7/365. And normally, the screed program only runs for a few weeks. I just can't imagine how someone could come up with such a consumption.

But I also have no idea what consumption we had during the construction phase back then, since the construction power was supplied directly through the shell builder and was basically included upfront in the shell construction price. So we had no separate billing for construction power.

On the topic, a few weeks ago we received our construction power bill on which we supposedly
consumed 46,000KWH – you can imagine the amount of the bill.

Based on your information, or rather the lack thereof, no qualified answer can be given.

During our renovation in May 21 the screed was poured including the heating-up program via air-water heat pump

September 20 to Feb 21 (without significant consumers)
Then from the end of March 21 to Nov 21.
Due to a lack of meters, we received our meter in April 22. This means from November to April in the inhabited condition, the power was drawn via construction power.

That means you had construction activities from 09/20 - 02/21 over the meter, but only usual construction machines (driller, mixer, lamps, etc.).
How was the heating done? Was there any heating at all? That can already add up, it’s a whole winter.
Then the heating-up phase for the screed over the summer. How large is the house and the screed? Generally, the heating-up phase in May via air-water heat pump should not consume that much, maybe 1,000 kWh / 100 m².

BUT then you heated the house, an additional whole winter and also lived in it. So it is not construction power, but the electricity you need for normal use and I have just a stupid suspicion...
You write it’s not a new build. What is the energetic standard of the house and how big is it? Was the underfloor heating well insulated against the ground? In existing buildings, the build-up height can’t easily be changed.
Your devices, 2 large air-water heat pumps with 10 kW heating capacity each, indicate a very large house, low energy standard, or a careless planner. What are the data here?
These are all factors that can lead to high consumption, but without values, nothing can be recalculated or evaluated.

Since April we have been running normally and can now see that so far in the inhabited condition with heating and hot water etc. we have used 5,000KWh

If you subtract 1,500 kWh for household electricity without heating (which is already a lot), 3,500 kWh remain.
Since the heating share from April to September should only be very low, at most still present in April, a large part of that would have been used for hot water. 3,500 kWh corresponds to about 12,000 kWh of heat (high COP for heating in April and also high COP for hot water in summer). Other new builds use that in a whole year for heating and hot water, which is also way too much for a normally sized single-family house.
The same applies here: data on the house and usage (people, special equipment, e-car?) are missing, otherwise it cannot be evaluated.

They are 2 Daikin Altherma 3 H HT 14 KW each with 9KW backup heating (heating rod). Air/water heat pump

That is quite a lot for a single-family house.

How high is the consumption with such a screed program?

Our screed program used 2200 kWh, December-January. (185m² screed)

How high is the consumption for such a screed program?

We had a thread on this topic last week (?) and I did a bit of googling. The rule of thumb is up to 20 kWh/sqm, also depending on the weather. 46,000 kWh is beyond good and evil.