Quite simple, if there isn’t regularly air movement (in the ducts), condensate will sooner or later form and create a perfect breeding ground for mold together with dust.
So even during vacation, it’s better to keep it running at a minimum.
The most important argument has already been mentioned by Tolentino.
If air stands still in the pipes, dust, moisture, and thus mold and other unwanted things can accumulate.
This is especially problematic with floor outlets or air ducts exposed to cold.
Our (Recovair) can’t even be turned off.
You have to unplug it to change the filter.
Well, I’m not arguing for keeping it off all the time, but for reducing it. For example, you could run it for 2 hours and then turn it off for 2 hours. Or, since cooking was mentioned here as an argument: turn it off for 4-5 hours at night and run it in the afternoon... whatever fits the habits best.
At the same time, I believe the argument about mold is incorrect: We are actually talking about the case where the humidity is too low. So what moisture would condense here? Especially since the ventilation shouldn’t be touching cold pipes. In a single-family house, it will certainly be installed about 95% in the ceiling. Probably even right next to the underfloor heating ;)
Dust deposits: With floor outlets, yes, okay, dust can fall onto the outlet. And then? It certainly wouldn’t be sucked back in through the outlet.
With inlets, you only get dust ingress when the ventilation is running (I don’t know of any floor inlets).
My ventilation explicitly has control programs to manage this. Even better, the humidity of the outgoing air is monitored! If it’s too low, I can automatically turn off the ventilation. That is even explicitly intended by the inventor.