I find the order of the sanitary fixtures especially important: entrance --> washbasin --> toilet. After that come practical things like "accessibility" in the sense of: no dead spaces or having to squeeze past sanitary fixtures when opening/closing doors. Therefore, let the door open towards the hallway, which is also easier in case of an injured person because they do not block the door. After that, installation-related/practical things such as wastewater pipes, possibly acoustics (sound) / toilet not on interior walls to living spaces.