Oh, with KNX you can operate any system, you don’t necessarily need a specific integration for that. The technology inside is simple, there’s nothing you have to keep. It just adds an interface. Of course, with a "proper gateway" you get a bunch of parameters and control knobs that come with the manual controls, but you have to decide for yourself if you want to bear the additional costs for that.
A few actuator channels and a few sensors, and you can control and monitor all sorts of things even without native KNX integration.
CO2 and VOC sensors are a huge gain in any system, no matter how it is operated/controlled on a higher level. But here it’s like the saying goes: "You don’t miss what you don’t know."