No. Unless you have too much money. Only air-water heat pump, properly sized. In addition, a proper building envelope and, if you will, a small installation spacing.
Do an HLB and consult a specialist. With your information, it is only possible to insufficiently assess whether an air-to-water heat pump is suitable or not and whether there are viable alternatives.
We live in the area where Hessen/Bavaria (Rhön) & Thuringia border each other - NES region.
We are building a prefabricated house with 150 sqm, building envelope kfw40/Energy Saving Ordinance 2016.
We decided on a Stiebel Eltron LWZ 504 (air-water heat pump + controlled residential ventilation combo).
Gas is also not available at our location.