Primed gypsum plaster in new construction — silicification?

No, I am not an expert. But honestly, I am at a loss for words. Luckily, as a building physicist you need a degree, or the master painter a long-term training. Fortunately, many years of acrylic painting do not count as a sideways entry.

This is not a lateral entry but something that you can only properly learn with us in Munich or in Italy, and not at the [Baumschule] but in the master class, because the Bavarians still have [Lüftlmalerei]. Attempts on drywall sample boards would confirm to you that mineral applications are still almost completely washable after 2-3 weeks under good climatic conditions where crystal formation must be complete. Gypsum also forms crystals, that’s true. Its crystalline bonds become shorter each time it gets wet. Then it becomes softer. You can see this well with very hard molding gypsum, from which, for example, molds for roof tiles are made. The molds can only be used for a few weeks. You also cannot re-harden them with silica, which is possible with classic mineral material, see monument restoration. I have had the pleasure several times to work on projects with such historic material.

The mold-inhibiting effect can be maintained in the mix, but silicification cannot. This was about silicification as far as I understood. Our trades could definitely have benefited a lot from each other, I think that the term mineral in my field might have been defined more narrowly but still applied meaningfully.
Best regards
Gabriele

First of all, thank you for your answers. You can see there are many possibilities. Or as Fernandel once said: "Whatever may come, there is always someone who knows better." For laypeople like me, much of the technical language is simply gibberish. My question was simply whether the primer/base coat delays/reduces/prevents any processes triggered by the paint. I just don't really want it to lead to mold growth in a few years that I could have prevented (aside from airing out, etc.).